Development of Protein Crystallography from Structural Biology to Biological Structural Chemistry

Abstract

A history of protein crystallography is looked back over for the past forty years where out-standing methodological development has been made. Protein crystallography has become one of well matured experimental techniques and made a great contribution to remarkable progress in the field of structural biology. Particularly in advance of the last decade, ultrahigh resolution structure analyses of protein crystals enabled us to visualize distribution of outer-electron density which implies that new era to understand chemistry of protein reaction from crystal structures will come soon.