Nihon Kessho Gakkaishi
Online ISSN : 1884-5576
Print ISSN : 0369-4585
ISSN-L : 0369-4585
New Challenges in Structural Biodynamics in Physiological Environment
Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR
Takumi UEDAYutaka KOFUKUKoh TAKEUCHIShunsuke IMAIYutaro SHIRAISHIIchio SHIMADA
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JOURNAL FREE ACCESS

2022 Volume 64 Issue 4 Pages 279-284

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Abstract

NMR methods provide information about conformational dynamics of GPCRs over a wide range of frequencies in aqueous media at near-physiological temperature, with minimal modification of the wild-type GPCR covalent structures. Here we review our solution NMR studies of the functionrelated conformational dynamics of GPCRs, including β2 adrenergic receptor, μ opioid receptor, and adenosine A2A receptor.

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© 2022 The Crystallographic Society of Japan
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