骨腫瘍との鑑別を要した Erdheim-Chester 病の一例

相澤 淳一; 坂山 憲史; 木谷 彰岐; 宮脇 城二; 亀井 節也; 山本 晴康; 宮崎 龍彦; 菅原 敬文; 佐田 榮司

doi:10.11360/jcsoa.19.267

original papers

A Case of Erdheim-Chester Disease

Junichi Aizawa, Kenshi Sakayama, Teruki Kidani, Joji Miyawaki, Setsuya Kamei, Haruyasu Yamamoto, Tatsuhiko Miyazaki, Yoshifumi Sugawara, Eiji Sada

Author information

Junichi Aizawa
Department of Orthopedic Surgery Ehime University School of Medicine
Kenshi Sakayama
Department of Orthopedic Surgery Ehime University School of Medicine
Teruki Kidani
Department of Orthopedic Surgery Ehime University School of Medicine
Joji Miyawaki
Department of Orthopedic Surgery Ehime University School of Medicine
Setsuya Kamei
Department of Orthopedic Surgery Ehime University School of Medicine
Haruyasu Yamamoto
Department of Orthopedic Surgery Ehime University School of Medicine
Tatsuhiko Miyazaki
Department of Pathogenomics Ehime University School of Medicine
Yoshifumi Sugawara
Department of Diagnostic and Therapeutic Radiology Ehime University School of Medicine
Eiji Sada
Department of Medical Technology Ehime Prefectural University of Health Sciences

Keywords: Erdheim-Chester Disease, Treatment, Methotrexate

JOURNAL RESTRICTED ACCESS

2007 Volume 19 Issue 2 Pages 267-270

DOI https://doi.org/10.11360/jcsoa.19.267

Details

Abstract

Erdheim-Chester disease is a rare non-Langerhans form of histiocytosis. We report the case of a 40-year-old man who presented with bone pain. Both femurs showed diffuse and symmetrical sclerosis on plain radiographs, CT, and Gd-MRI. Specimens obtained on open biopsy fulfilled the criteria of Erdheim-Chester disease. The patient was treated with prednisolone (20mg/day), methotrexate (7.5mg/week), and bisphosphonate (5mg/day), and has achieved a sustained clinical response.

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