Abstract
We reported three cases of leg ulcer in patients with rheumatoid arthritis (RA) treated with low doses of methotrexate (MTX).
General conditions of all patients were stable and the activities of RA were well controlled. The ulcerations were induced by trauma or surgical intervention, however, there was no sign of cutaneous vasculitis. Skin ulcerations had been refractory to conserve therapy for over 5 months (Cases 1 and 2). After discontinuation of MTX, all cases were resolved successfully within 4 weeks.
It is considered that the toxicity of MTX probably delayed wound healing even at a low dose.
