Abstract
We report two cases of treatment of chronic osteomyelitis of the tibia and infection following total hip arthroplasty (THA) using hydroxyapatite (HA) impregnated with antibiotics. In both cases, after curettage and debridement HA impregnated with vancomycin (VCM) and gentamycin (GM) was inserted. Both cases, infection did not recurrented after the operation. We measured the serum and local concentration of antibiotics after inserting the HA impregnated with antibiotics. Both cases maintained low serum concentration and high local concentration. We obtained good results in treatment of bone and infection using HA impregnated with antibiotics.
