Abstract
Cushing's syndrome is a chronic hypersecretion of adrenocortical hormones with pathognomonic symptoms. The authors encountered a case of Cushing's syndrome with multiple pathological fractures and osteoporosis. A 30-year-old male had remarkable osteoporosis and multiple pathological fractures in Th7, bilateral costae and ischia. This case was diagnosed as Cushing's syndrome accompanied by adrenocortical tumor based on findings in endocrine test, X-P, CT, scintigraphy, and others. As a treatment, a surgical excision was carried out. The tumor was shown to be adenoma. The osteoporosis and multiple pathological fractures are steadily healed by this treatment.