Abstract
We analysed the effect of cisplatin, which is the most common anti-neoplastic agent for the treatment of malignant bone and soft tissue tumors, on regeneration of the peripheral nerve.
Left sciatic nerve of Wister rat was elected for Site of neurorrhaphy. Three groups of rats were prepared as follows, Group 1: Cisplatin of 6mg/kg was weekly administrated throgh the tail vein after neurorrhaphy. Group 2: The dosage of cisplatin was 1.5mg/kg, it was administrated in the same manner. Group 3: Saline were injected in the same manner as a control. Each group consists of 12 rats, and they were functinally assessed by sciatic functional index 6 weeks after neurorrhaphy. After sacrifice, each specimen was histrogically evaluated.
The results showed no significant differences among three groups so far, and any adverse effect of cisplatin on nerve regeneration was proved.
