Abstract
Inorganic nanomaterials hybridized with other functional inorganic, organic, and/or bio molecules are attracting great interest in science and technology. This review demonstrates the bio-inorganic nanohybrids with drug delivery function, where drug or gene molecules are intercalted into the layered double hydroxide (LDH), anionic clay. The enhanced drug efficacy of drug-LDH nanohybrids are described in detail with the biocompatibility of LDH, delivery vehicle. According to the cellular uptake experiments on various cell culture lines, we could conclude that the LDH nanoparticles are internalized into cells via clathrin-mediated endocytosis, delivering encapsulated drugs efficiently.
