A Study on the Irritation Test Method in Oral Mucosa

Report 1: A Consideration of Irritation of Dextranase in Oral Mucosa

Abstract

Generally eye and skin irritation tests havebeen used in examining irritation caused by medicine and cosmetics. However, it is questionable if the results obtained through these irritation tests directly represent levels of irritation in the oral mucosa caused by dentifrice and its confined agents because mucosa tissue and physiological functions of oral mucosa differ from those of eye or skin. Authors have considered another test method, used in the oral cavity, for the irritation of agents combined in dentifrice, and this method appears to be superior to the conventional eye irritation test method.