PFAS Non-target Analysis

Abstract

High-resolution mass spectrometry (HRMS) generates data rich in analytical information. When combined with chromatography, this technology enables non-target analysis—an approach that identifies compounds without predetermined analytical targets. This methodology shows particular promise for PFAS research, where many fundamental questions about these contaminants remain unanswered. Non-target analysis may provide crucial insights needed to resolve ongoing PFAS-related challenges.

This review examines the value of HRMS data alongside complementary analytical techniques that enhance its capabilities. The discussion outlines key considerations for selecting and applying different analytical approaches, focusing on how to distinguish between various applications and implement them effectively in environmental analysis.