A Case of Multiple Fixed Drug Eruption Induced by Mesilate Garenoxacin (Geninax^®) Successfully Treated with High Dose Systemic Corticosteroids

Abstract

　A 26-year-old man who had taken some medicines, including mesilate garenoxacin (Geninax^®) , for pharyngitis, developed lip swelling and multiple erythematous lesions on the limbs and the body with high fever. He was successfully treated with discontinuance of suspected medicines and high dose oral prednisolone (1 mg/kg ; 60 mg daily) . Oral provocation test with mesilate garenoxacin was positive, whereas both patch test and DLST (drug-induced lymphocyte stimulation test) were negative. He was diagnosed with multiple fixed drug eruption caused by mesilate garenoxacin. Multiple fixed drug eruption has been most commonly reported among drug eruptions induced by mesilate garenoxacin. Severe cutaneous symptoms with high fever were induced after oral provocation test with mesilate garenoxacin at a dose of 40 mg (one-tenth of a single dose) in our case. Therefore, more attention should be paid to dosage of mesilate garenoxacin for oral provocation tests in order to not induce severe symptoms.