Abstract
A quantitative genetic risk assessment has been recognized as one of the goals of the research of environmental mutagens. To establish the genetic risk assessment as a practice routinely applicable to daily tasks, a collaborative study was carried out from 1996 to 1999 in the Mammalian Mutagenesis Study Group. Mitomycin C was selected as a model compound and its genetic risk was quantitatively assessed for autosomal dominant and X linked genetic diseases. In this paper, outcomes of the study are presented together with the recent progress in a genetic risk assessment on radiation.
