Immunohistochemical Localization of Inhibin α-Subunit in Two Equine Granulosa-Theca Cell Tumors

Wendell P. DAVIS; Mohamed S. MEDAN; Wan Zhu JIN; Roger E. WELLS; Gen WATANABE; Kazuyoshi TAYA

doi:10.1294/jes.16.45

CASE REPORT

Immunohistochemical Localization of Inhibin α-Subunit in Two Equine Granulosa-Theca Cell Tumors

Wendell P. DAVIS, Mohamed S. MEDAN, Wan Zhu JIN, Roger E. WELLS, Gen WATANABE, Kazuyoshi TAYA

Author information

Wendell P. DAVIS
New Hampshire Veterinary Diagnostic Laboratory and the Department of Animal and Nutritional Science, University of New Hampshire
Mohamed S. MEDAN
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University
Wan Zhu JIN
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Roger E. WELLS
New Hampshire Veterinary Diagnostic Laboratory and the Department of Animal and Nutritional Science, University of New Hampshire
Gen WATANABE
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Kazuyoshi TAYA
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University

Keywords: granulosa-theca cell tumor, inhibin, mare

JOURNAL FREE ACCESS

2005 Volume 16 Issue 2 Pages 45-49

DOI https://doi.org/10.1294/jes.16.45

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Abstract

Granulosa-theca cell tumor (GTCT) is the most common ovarian tumor in mares. Two adult Arabian mares presented with a history of persistent estrus (No. 1) and aggressive behavior (No. 2). Large unilateral polycystic ovarian masses were identified in each mare on rectal and ultrasound examinations. The masses were surgically removed and subjected to immunohistochemical staining. The histopathologic features of both ovarian masses were consistent with GTCT. Both tumors displayed positive immunoreactivity for inhibin α-subunit, but were negative for inhibin βA and βB subunits. This report indicates that appearance of inhibin α-subunit can be used as an immunohistochemical marker in the diagnosis of GTCT in equine.

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