Hereditary Spherocytosis Presenting with Immunoglobulin A Nephropathy in Post-Splenectomy

Abstract

Hereditary spherocytosis is a familial hemolytic anemia. In this report, we describe a rare case of hereditary spherocytosis complicated by IgA nephropathy which was successfully treated with an angiotensin converting enzyme inhibitor. This is the first time that such a case in an adult has been documented. We describe a 72-year-old Japanese male who presented with hereditary spherocytosis, accompanied by Immunoglobulin A nephropathy. The patient had renal dysfunction, proteinuria, and hematuria. The patient was treated with an angiotensin converting enzyme inhibitor, resulting in clinical improvement. Clinicians should recognize that hereditary spherocytosis with IgA nephropathy can occur in the post-splenectomy patients.