Abstract
The purpose of this study is to scrutinize clinical applicability of disinfection approach in endodontic treatment devised by Hoshino et al. Despite its sound principle, clinical records and reports are scarce. As such, this report presents a summary of cases of disinfection endodontic treatment based on anaerobic culture system at the chair-side. This procedure aims to preserve as much carious dentin as possible, by locally applying to the infected sites antibiotic mixture of minocycline, metronidazole and ciprofloxacin and in order to enhance operability and osmosis, macrogol and propylene glycol are added to the antibiotic mixture (hence, 3Mix-MP® procedure). Due to prolongation of consultation time, application of this procedure was limited to advanced cases with at least one of the four conditions: 1) periapical lesion; 2) prolonged endodontic treatment; 3) acute symptoms; 4) difficult to perform root canal enlargement. For most of cases the antibiotic mixture proved effective against bacterial culture. When cultivatable bacteria was no longer detected in the sample of infected root canal content incubated at the chairside, the root canal was filled. With this approach out of 95 (including 30 unknown) cases only two resulted in adverse prognosis. This suggests clinical utility of the procedure, considering the selection criteria, though confirmation by further clinical researches is imperative.
