The Influence of Diabetes Mellitus on Plaque Volume and Vessel Size in Patients Undergoing Percutaneous Coronary Intervention

An Intravascular Ultrasound Study

Abstract

We evaluated the influence of diabetes on plaque volume and vessel size at a reference segment in diabetic patients undergoing percutaneous coronary intervention using both angiograms and quantitative intravascular ultrasound. A total of 344 patients with 449 de novo coronary lesions including 97 diabetics (133 lesions) who underwent elective percutaneous coronary intervention under intravascular ultrasound guidance were included in this study. Eleven diabetic patients (19 lesions) received insulin and 52 patients (77 lesions) oral hypoglycemic drugs. The other 34 patients (37 lesions) received diet/exercise therapy alone. We measured vessel area (VA) and lumen area (LA) at proximal and distal reference segments by intravascular ultrasound, which were averaged. Plaque area (VA-LA) and % plaque area (100 × plaque area/VA) were subsequently calculated. Although VA was similar between diabetic and non-diabetic patients (13.46 ± 4.49 mm² in diabetics versus 14.11 ± 5.24 mm² in non-diabetics, P = 0.214), LA was smaller (6.51 ± 2.63 mm² versus 7.38 ± 3.08 mm², P = 0.004) and % PA was larger (50.4 ± 11.7 versus 46.5 ± 11.3, P < 0.001) in diabetic patients, especially the group receiving a hypoglycemic drug or insulin. VA, LA, and % PA were similar between patients with and without insulin treatment. These results potentially might cause undersized device selection without intravascular ultrasound guidance.