Abstract
Coronary Artery Bypass Graft (CABG) is known to induce oxidative stress and the use of CoQ10 preoperatively is noted to reduce oxidative stress response. This study aims to evaluate the benefit of giving CoQ10 in patients undergoing CABG specifically determining its effects on reperfusion arrhythmias and its myocardial protection against stress and injury as measured by cardiac enzymes and inotropic requirements. Prospective, randomized blinded trials were included in this metaanalysis. A systematic search of Google, Wiley interscience, Cochrane and Pubmed Database of the National Library of Medicine, from 1993–2010, and a manual search of other relevant journals were conducted. RevMan 5 was used in Data Analysis. Four randomized controlled trials were included in the review. There was a significant effect of Coenzyme Q10 in preventing reperfusion arrhythmias with an odds ratio of 0.20 at 95% CI. Comparing patients treated with CoQ10 to placebo, there was no significant difference on cardiac enzymes with standard mean difference of −0.48 at 95% confidence interval. Inotropic requirements were noted to be lower in patients treated with Coenzyme Q10 with standard mean difference of −3.18 at 95% confidence interval. Preoperative treatment of CoQ10 could improve clinical outcome of patients who underwent CABG by decreasing reperfusion arrhythmias and inotropic requirements. However, it has no significant effect in cardiac enzyme levels post-CABG.
