Abstract
We examined the expression of HSP70 in acute lung injury induced by lipopolysaccharide (LPS), in order to explore the mechanism of HSP70 in acute lung injury. Using an acute lung injury model in Wistar rats, we observed the in vivo HSP70 expression by immunohistochemistry and Western blot. After exposure to LPS, the level of HSP70 increased above the control level at 1 hour, reached the maximum level at 2 hours, and returned to the control level by 6 hours. Our study suggested that the expression of HSP70 is involved in the protection of acute lung injury induced by LPS.
