Comparative Study of Two Different Structures of Collagen Scaffold for Bone Formation

Andrea Paola Rodriguez; Hitoshi Nagatsuka; Bingzhen Huang; Kan Rui; Mika Okauchi; Yoshie Kagawa; Missana Liliana; Shinichiro Oida; Noriyuki Nagai

doi:10.2485/jhtb.14.210

International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005

Comparative Study of Two Different Structures of Collagen Scaffold for Bone Formation

Andrea Paola Rodriguez, Hitoshi Nagatsuka, Bingzhen Huang, Kan Rui, Mika Okauchi, Yoshie Kagawa, Missana Liliana, Shinichiro Oida, Noriyuki Nagai

Author information

Andrea Paola Rodriguez
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hitoshi Nagatsuka
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Bingzhen Huang
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Dental Titanium Giken
Kan Rui
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Dental Titanium Giken
Mika Okauchi
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yoshie Kagawa
Japan Institute for Advanced Dentistry
Missana Liliana
Tucuman University
Shinichiro Oida
Tsurumi University, Dental School
Noriyuki Nagai
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Keywords: Honeycomb porous structure, Interconnected porous structure, KUSA/A1 cells

JOURNAL FREE ACCESS

2005 Volume 14 Issue 2 Pages 210-211

DOI https://doi.org/10.2485/jhtb.14.210

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Abstract

It has not been determined the best scaffold-structure for bone engineering. Because of this, we compared Honeycomb porous structure (HPS) and Interconnected porous structure (IPS) with or without KUSA/A1 cells implanted in mice. The transplants were subjected to radiological and histological examinations after 1,2,4 and 8 weeks of implantation.
KUSA/A1 cells alone showed small islands of new bone. Both scaffolds alone did not reveal any bone induction. KUSA/A1-HPS presented the scaffold partially filled with new bone. In contrast, KUSA/A1-IPS showed the whole scaffold filled with new bone. Our results indicated that cotton structure plays an important role in carrying the cells giving the precise size, shape and comfortable environment.

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