Liver Organogenesis from Murine Embryonic Stem Cells

Yoh-ichi Tagawa; Shinichiro Ogawa; Masaru Tsutsui; Akiko Kamiyoshi; Eisuke Tomioka; Shunsuke Kobayashi; Kenji Miki; Ryusei Isi; Jun Nakayama; Yasuhiko Hashikura; Fumiyasu Sato; Masahiko Nishiyama; Toshihiro Akaike; Shinichi Miyagawa

doi:10.2485/jhtb.14.263

International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005

Liver Organogenesis from Murine Embryonic Stem Cells

Yoh-ichi Tagawa, Shinichiro Ogawa, Masaru Tsutsui, Akiko Kamiyoshi, Eisuke Tomioka, Shunsuke Kobayashi, Kenji Miki, Ryusei Isi, Jun Nakayama, Yasuhiko Hashikura, Fumiyasu Sato, Masahiko Nishiyama, Toshihiro Akaike, Shinichi Miyagawa

Author information

Yoh-ichi Tagawa
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Shinichiro Ogawa
Department of Surgery, Shinshu University School of Medicine
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinshu University
Masaru Tsutsui
Division of Toxicological Research, Kissei Pharmaceutical Co. Ltd.
Akiko Kamiyoshi
Department of Organ Regeneration, Shinshu University School of Medicine
Eisuke Tomioka
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Shunsuke Kobayashi
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Kenji Miki
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Ryusei Isi
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Jun Nakayama
Department of Pathology, Shinshu University School of Medicine
Yasuhiko Hashikura
Department of Surgery, Shinshu University School of Medicine
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinshu University
Fumiyasu Sato
Division of Toxicological Research, Kissei Pharmaceutical Co. Ltd.
Masahiko Nishiyama
Division of Toxicological Research, Kissei Pharmaceutical Co. Ltd.
Toshihiro Akaike
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Shinichi Miyagawa
Department of Surgery, Shinshu University School of Medicine
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinshu University

JOURNAL FREE ACCESS

2005 Volume 14 Issue 2 Pages 263-264

DOI https://doi.org/10.2485/jhtb.14.263

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Abstract

Our purpose in the present study was to establish a system for in vitro hepatic morphogenesis, consisting of not only hepatocytes but also cell lineages supporting hepatic differentiation, such as cardiomyocytes and endothelial cells, from murine ES cells. We succeeded in establishing a novel system of hepatic morphogenesis from murine ES cells based on naturally occurring embryological events.

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