The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

Seigo Ohba; Hitoshi Yoshimura; Junichi Kobayashi; Kyoko Ishimaru; Shinpei Matsuda; Naoki Katase; Yoshiaki Imamura; Takaaki Ueno; Kazuo Sano

doi:10.2485/jhtb.22.147

Clinical Report

The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

Seigo Ohba, Hitoshi Yoshimura, Junichi Kobayashi, Kyoko Ishimaru, Shinpei Matsuda, Naoki Katase, Yoshiaki Imamura, Takaaki Ueno, Kazuo Sano

Author information

Seigo Ohba
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui
Hitoshi Yoshimura
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui
Junichi Kobayashi
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui
Kyoko Ishimaru
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui
Shinpei Matsuda
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui
Naoki Katase
Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
Yoshiaki Imamura
Division of Surgical Pathology, University of Fukui Hospital
Takaaki Ueno
Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Osaka Medical College
Kazuo Sano
Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui

Keywords: Osteoradionecrosis of the jaw (ORNJ), Hyperbaric oxygen therapy (HBO), Radiation therapy

JOURNAL FREE ACCESS

2013 Volume 22 Issue 1 Pages 147-152

DOI https://doi.org/10.2485/jhtb.22.147

Details

Abstract

The object of this study was to estimate the influence of radiation therapy (RT) and hyperbaric oxygen therapy (HBO) on osteoradionecrosis of the jaw (ORNJ). This retrospective study included patients who were diagnosed with ORNJ from 1998 to 2012 (15 years) and who recieved a total dose of RT (Gy) for the duration of the study. The duration of ORNJ development and the healing period of ORNJ were examined. The mean dose of RT was 64.0 Gy. The mean healing period of ORNJ was 30.3 months in the continuous RT group, and 20.8 months in the pre- and post-operative irradiation group. The healing term for ORNJ with HBO was approximately the same as that without HBO. We concluded continuous RT may induce more severe ORNJ than pre- and post-operative RT, and that the effectiveness of HBO on ORNJ is suspicious.

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