Abstract
In Dhaka 2013, autografts of demineralized dentin matrix (DDM) were first used as bone regenerative therapy with two patients in Bangladesh. In Case 1, a 29 year-old male presented with an infected periapical lesion involving #11 and #12. Root canal treatment followed by periapical surgery were done to remove the lesion. Tooth-derived granules were prepared from a vital non-functional tooth (#38) by hand-operated crush method, demineralized in 2 % HNO3 for 30 min and washed vigorously. DDM was grafted in the bone defect after the extirpation of the lesion. At 1 year after DDM graft, post-operative radiography indicated excellent bone healing by remodeling with dentin matrix. The pathological diagnosis was radicular granuloma. In Case 2, a 20 year-old female presented with a mesially inclined impacted 3rd molar (#48). Extraction of the impacted tooth and the autograft of the DDM were done simultaneously. Post-operative radiographs showed the extracted socket healed fully with new bone. The patient-own DDM granules from non-functional teeth could be recycled as osteoinductive materials for local bone regeneration. This works suggest that dentin might become a realistic alternative biomaterial to bone.
