Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

Abstract

Demineralization procedure of dentin and bone is well known to reduce the antigenicity and immunogenicity of allogenic dentin matrix as well as promote inactivation of transmissible viral disease. This study aims to evaluate the effectiveness of allogenic, demineralized dentin matrix (DDM) for alveolar bone repair. Clinical findings indicate that the healing process may be as effective as that observed with autogenous DDM. From 2013 to 2016, eighteen patients who underwent socket preservation with allogenic DDM were selected for evaluation of early complications at the surgical stage and for histological evaluation during a secondary surgical procedure at the Seoul National University Bundang Hospital and Seoul In Dental Clinic. They were monitored during the initial 7 to 10 postoperative days for observing the related immune responses. Like with autogenous DDM, no remarkable early and late complications were observed to result with the use of allogenic DDM. Additionally, the effect of bone regeneration was very similar to that found with autogenous DDM. Within the limitations of this study, the clinical results of allogenic DDM were similar to those of autogenous DDM.