2019 Volume 28 Issue 1 Pages 31-36
Objective: This study aims to analyse the cellular compatibility of the membrane made of poly (propylene carbonate) (PPC) and nanohydroxyapatite (nHAp) by solvent casting/particulate leaching. Experimental Methods: Observating the surface characters of different compositions nHAp/PPC membrane (0 wt%, 10 wt%, 20 wt%, 30 wt%, and 40 wt% nHAp), and evaluating its compatibility with MG63 cells. Results: Scanning electron microscopy showed that with the increased nHAp content, the roughness of the membrane surface increased. The results from our in vitro studies indicated that the MG63 cells cultured with nHAp/PPC membrane did not appear to have cytotoxic responses, and the nHAp/PPC membrane could improve the proliferation of MG63 cells when compared to controls (p < 0.05). Additionally, the cell activity, total protein, and alkaline phosphatase increased with the increased nHAp content.
