A Novel Biodegradable Hollow Nanocarrier Consisting Superparamagnetic Fe3O4-loaded poly-γ- glutamic Acid and Chitosan Oligosaccharide for Targeted Delivery of Sulforaphane from Broccoli Seed Extracts

Chengchuan Che; Yuan Li; Xinxin Liang; Zhijin Gong; Jinfeng Liu; Ge Yang

doi:10.2485/jhtb.28.297

Research Note

A Novel Biodegradable Hollow Nanocarrier Consisting Superparamagnetic Fe₃O₄-loaded poly-γ- glutamic Acid and Chitosan Oligosaccharide for Targeted Delivery of Sulforaphane from Broccoli Seed Extracts

Chengchuan Che, Yuan Li, Xinxin Liang, Zhijin Gong, Jinfeng Liu, Ge Yang

Author information

Keywords: Superparamagnetic iron oxide nanoparticles, Poly-γ-glutamic acid, Chitosan oligosaccharide, Nanocarrier, Sulforaphane

JOURNAL FREE ACCESS

2019 Volume 28 Issue 3 Pages 297-302

DOI https://doi.org/10.2485/jhtb.28.297

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Abstract

The aim of this study was to synthesize a polymeric nanocarrier system loaded with superparamagnetic iron oxide nanoparticles (SPION) and the sulforaphane(SFN) through a cross-linking method in order to protect the SFN. According to this experiment, the drug-loading content and encapsulation efficiency were 29.97±0.08% and 0.34±0.41%, respectively. The total cumulative amount of SFN, released from the nanocarrier in vitro was 87.90% over a 72 h period. MTT assays indicated that the SPION-SFN-loaded nanocarrier exhibited a much higher in vitro antitumor efficacy than free SFN. Together, these results indicate that SPION-loaded nanocarrier exhibits good drug-loading ability and sustained-release function.

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