Cytokeratin 8 Promoted Sinonasal Inverted Papilloma Malignant Transformation to SNSCC

Abstract

The sinonasal inverted papilloma is one of the more common benign tumors of the nasal cavity and sinus. It originates from the schneiderian membrane. It has the characteristics of easy recurrence and malignant transformation. This experiment found that Cytokeratin 8 expression increased in the sinonasal inverted papilloma. To better detect the role of Cytokeratin 8 in the proliferation and deterioration of the sinonasal inverted papilloma, we divided the sinonasal inverted papilloma into NIPN, NIPAP, and NIPAH by histological. The expression of Cytokeratin 8 in the sinonasal inverted papilloma was detected by immunohistochemistry. We found that the increased expression of Cytokeratin 8 was consistent with the invasion of sinonasal squamous cell carcinoma. In vitro, it was found that after Cytokeratin 8 interference, the proliferative and invasion of head and neck squamous cells were decreased. Cytokeratin 8 played an important role of sinonasal inverted papilloma malignant transformation to sinonasal squamous cell carcinoma. Inhibition of Cytokeratin 8 could diminish the proliferation and block the invasion of head and neck squamous cells.