2024 Volume 33 Issue 4 Pages 183-188
Osteoarthritis (OA) is a type of prevalent degenerative joint disease featured by cartilage breakdown, inflammation, as well as pain, leading to significant disability. Inflammation, mediated by cytokines such as IL-1β, plays a central role in OA pathogenesis. Cirsilineol (CSL), a bioactive flavonoid, has shown anti-inflammatory and antioxidant properties in various models, however, its effects on OA remains unclear. This research was to investigate the effects of cirsilineol on IL-1β-stimulated apoptosis as well as inflammatory response in human osteoarthritic chondrocytes. Herein, we revealed that CSL improves cell viability in human osteoarthritic chondrocytes. Furthermore, CSL was shown to effectively suppress the IL-1β-stimulated inflammatory response. Additionally, CSL inhibited the IL-1β-stimulated remodeling of ECM. Notably, the protective effects of CSL were associated with the suppression of the NF-κB pathway. In conclusion, CSL inhibits IL-1β-stimulated apoptosis and inflammatory response in human osteoarthritic chondrocytes via mediating NF-κB pathway, and could therefore serve as a drug of OA.
