Relationship between tonsil induced autoimmune/inflammatory syndrome (TIAS) and tonsillar bacterial flora

Abstract

We summarized our basic and clinical studies regarding tonsillar focal disease. We think that the pathogenesis of tonsillar focal disease is hyper-activation of tonsillar lymphocytes against tonsillar commensal bacteria and bacterial DNA followed by over-expression of several homing receptors on tonsillar T-cells and over-production of IgA from tonsillar B-cells. We called the disease caused by this series of abnormal immunological response tonsil induced autoimmune/inflammatory syndrome (TIAS). Disease severity of pathologies such as palmoplantar pustulosis, IgA nephropathy, and sternocostoclavicular hyperostosis are known to be ameliorated by tonsillectomy. Tonsillectomy should be recommended for patients with TIAS introduced by dermatologists, nephrologists, orthopedists, and other doctors.