Eosinophil cell death and otorhinolaryngologic diseases

Abstract

Eosinophil- and interleukin-5-targeted therapies are being utilized in clinical settings in recent years. It is important to understand the mechanisms underlying the behavior of eosinophils in vivo. Eosinophils are important etiopathogenetic contributors to otolaryngological diseases, such as allergic rhinitis, eosinophilic granulomatosis with polyangiitis, eosinophilic chronic rhinosinusitis, and eosinophilic otitis media. The recognition of programmed eosinophil death, which results in release of granule proteins and formation of extracellular traps and Charcot-Leyden crystals leads our research forward to gain deeper insight into the pathogenesis of eosinophil-mediated diseases.