Abstract
The clinical efficacy of olopatadine hydrochlorides was investigated in 58 patients suffering from Japanese cedar pollinosis at Ehime University Hospital and the related facilities between January and July in 2005. The 58 patients were divided into two groups ; medicated from the preseason (PM) and medicated during the season (DM). The patients' major nasal symptoms (sneezing, rhinorrhea, and nasal obstruction) and the quality of life of the patients were accessed using a questionnaire survey. Their symptom and symptom medication scores were also assessed and compared between the two groups. Sneezing was observed to improve in the PM group by the administration of olopatadine for two weeks, and major nasal symptoms were improved for two and four weeks after the treatment in the DM group. The QOL was improved by the administration for two and four weeks in both groups. The only complication was sleepiness, which was observed in one patient (1.7%) in the study. These results demonstrated that olopatadine hydrochlorides provided effective medication for patients with Japanese cedar pollinosis even in the patients during the pollen season.
