Abstract
Autonomic nervous drugs were administered to the nasal mucosa via nasal drops, and changes in the nasal microvasculature were visualized with the use of natural light and narrow band imaging. The following observations were reported : (1) The administration of 0.02% adrenalin (Bosmin®) induced vasoconstriction after a mean of 1.8 minutes. Vasodilation subsequently occurred after a mean of 4.4 minutes in all 13 subjects. (2) The administration of 0.5% sulbutamol sulfate (Venetlin®) had no significant effect in subjects without allergic rhinitis. (3) The administration of Venetlin® induced vasodilation after 5.0 minutes in 25% of patients with rhinorrhea-dominant allergic rhinitis. (4) The administration of Venetlin® induced vasodilation after a mean of 4.0 minutes in all patients with nasal obstruction-dominant allergic rhinitis. (5) Beta-adrenergic stimulants may promote the synthesis of leukotrienes and other mediators and may lead to nasal obstruction in patients with nasal obstruction-dominant allergic rhinitis. (6) The administration of an anticholinergic drug resulted in vasodilation in 85.7% of the patients with allergic rhinitis. (7) Hyper-responsiveness of muscarinic receptors may therefore occur in patients with allergic rhinitis.
