Abstract
Oncocytic carcinoma (malignant oncocytoma) is an extremely rare malignancy. We herein report two cases of oncocytic carcinoma arising from the submandibular gland and parotid gland. As these are minority cases, there are no established diagnostic criteria nor treatment policies. Case 1 was a 64-year-old male was diagnosed with primary parotid oncocytic carcinoma. We controlled the primary tumor through surgery and localized radiotherapy, but the patient developed distant metastasis two years after surgery and died four years after surgery later despite the use of chemotherapy. Case 2 was a 58 year-old male who was diagnosed with primary submandibular oncocytic carcinoma. We performed surgery as the first-line therapy. Chemotherapy using TS-1® (120 mg/day) was used for two weeks before surgery, and resulted in tumor shrinkage. The patient was able to undergo radical curative surgery, although he has been continuously followed up to identify any recurrence or metastasis.
