Abstract
The drug sensitivity of S. pneumoniae and H. influenzae isolated from children with acute otitis media or acute sinusitis in 2011 was investigated to assess the relationship between age and drug resistance as well as the drug sensitivity of antibacterial agents recommended in the treatment guidelines for pediatric acute otitis media and acute sinusitis. DRSP were detected significantly more frequently in children under 3 years of age in comparison to those 3 years of age or older, but there was no difference according to age for ABPC resistant H. influenzae. PSSP was more sensitive to AMPC than to CDTR, while PISP was more sensitive to CDTR than to AMPC. H. influenzae was the most sensitive to CDTR. The MIC90 of TBPM was 0.06 μg/ml for DRSP and 0.5 μg/ml for ABPC-resistant H. influenzae, thus suggesting that TBPM is the only antibacterial agent tested that had an MIC90 of 0.5 μg/ml for both of these drug-resistant bacteria.
