Abstract
A retrospective comparative study was conducted of patients using betahistine mesilate and those using a combination of betahistine and isosorbide jerry. Patients with Ménière's disease or suspected Ménière's disease based on their clinical symptoms were included in the study, and received 36 mg/day of betahistine or the same dose of a combination of betahistine and isosorbide jerry for three months. The basic dosage of isosorbide jerry was 90 g/day t.i.d, but the dose was reduced as appropriate according to improvement or drug compliance. Travelmin tablets were given in advance to be taken at the onset of vertigo attack. The outpatients that visited the hospital due to acute vertigo attack received intravenous drip infusion of 7 % sodium bicarbonate solution, and were temporarily hospitalized for treatment. The number of patients receiving Travelmin, the number undergoing drip infusion and the number of hospitalizations due to vertigo attack were significantly lower, and the reducereduction in the number of vertigo attacks was higher with the concurrent therapy with betahistine and isosorbide jerry in comparison to the betahistine monotherapy. These results showed that the long-term concurrent therapy with betahistine and isosorbide jerry was an effective treatment for prevention of vertigo attacks in clinical practice.
