Endoscopic surgery for sinonasal malignancies − A retrospective multicenter study on endoscopic management of esthesioneuroblastoma −

Abstract

Background：The aim of the present study was to illustrate the utility of the multilayer resection of esthesioneuroblastomas (ENB) using endoscopic endonasal approach (EEA). Methods：We retrospectively reviewed patients treated at 10 tertiary referral hospitals in Japan with a diagnosis of ENB. Results：A total of 32 patients (15 male；mean age at presentation, 51.3 years) underwent multilayer resection of ENBs using EEA. Thirty patients were newly diagnosed and two presented with recurrent disease. Dulguerov staging at presentation was T1, 6 patients；T2, 10 patients; T3, 8 patients；and T4, 8 patients. EEA alone was performed in 24 patients, and EEA with transcranial approachwas performed in 8 patients. The mean period of follow-up was 40.3 months. No post-operative complications were identified. Pathological margin studies revealed margin-free resections in 31 patients. All patients were alive at the last follow-up. Of the 14 patients who underwent EEA alone with olfaction preservation, olfaction was remained in 13 patients. Conclusions：The results of the present study indicate the safety and utility of multilayer resection using EEA for treatment of ENBs.