2020 Volume 66 Issue 1 Pages 10-15
Laryngeal papillomatosis (LP) has a high rate of recurrence. The main treatment is surgical excision, and various medicines have been administered as adjuvant therapy. Yokuinin, a Chinese medicine, has long been used as an adjuvant therapy for LP in Japan; however, there have been few reports on this topic. We studied the effects of the administration of Yokuinin as adjuvant therapy for LP. The subjects included 67 patients who were diagnosed with LP and who underwent surgery at Kyushu University Hospital from July 2000 to March 2018. Twenty-seven patients (40%) developed recurrent disease after surgery. Eight patients with recurrence were treated with oral Yokuinin as adjuvant therapy, while 19 patients with recurrent disease were treated without Yokuinin. The relapse-free periods of the Yokuinin treatment group and non-treatment group were compared; however, the difference was not statistically significant. We compared the period before therapy with that after treatment. Both the relapse-free and operation-free period was prolonged after the administration of Yokuinin. The administration of Yokuinin was found to extend the periods until recurrence and re-operation. These results suggested the potential usefulness of adjuvant therapy with Yokuinin.
