Abstract
A study was made of the distribution of neutralizing antibodies against adeno virus type 3, in sera of patients with chronic tonsillitis in Kumamoto district during the period from October 1963 to August 1965. Neutralizing antibody titer was regard from 1: 4 to 1: 16 and antibody titer which showed higher than 1: 4 serum dilution (positive) found in 42.2% of 415 patients with chronic tonsillitis, and less frequently in a control group of 64 persons without chronic tonsillitis (26.5%). The antibodies were more frequently seen in patients with both adenoid and chronic tonsillitis (61.9%) than in patients only with adenoid (35.2%).
104 cases with chronic tonsillitis and positive antibodies received tonsillectomy, of them a decrease in the titer was observed in 30 cases (28.8%) one month after tonsillectomy. However, adenotomy produced a decrease in the titer in only 3 cases out of 16.
Neutralizing antibodies against Adenovirus type 3 were found in the tonsil extracts in 5 out of 21 cases which showed positive antibodies in sera. The anti bodies in sera were found more frequently in patients with focal chronic tonsillitis than in those with simple chronic tonsillitis. Of systhemic diseases, the antibo dies were found most frequently in patients with slight fever, but percentage of positive (1: 4<) antibodies was about the same in the other systhemic diseases.
