Abstract
Sixteen patients of the head and neck malignancies in our ENT Clinic of Kyushu University Hospital were treated with bleomycin and the adequate results for nine patients in this series were obtained. In general, the combined treatment of irradiation and bleomycin is more effective on the tumor than bleomycin alone. In some cases, local injections of bleomycin directly into the tumor tissue made the most cancer cells degenerated and remarkably destroyed. Administration of bleomycin produced temporarily slight fever and poor appetite, however, it was almost harmless for patients on condition within 250mg of bleomycin. Even when combined irradiation and bleomycin, the leukocyt ecount in the circulating blood was not decreased. Bleomycin has proved to be useful agent especially in the treatment of squamous cell carcinoma of the head and neck.
