Abstract
Laboratory investigation with the Lincomycin (LCM) were performed with the results which may lead to the following conculsion. LCM concentration in blood: The method is a thin layer cup assay with Staphylococcus aureus FAD, JC-I in Mycinassay Agar (Difco). 600 mg of LCM in 250 ml. of five per cent glucose solution was administered to 5 normal adults (volunteers). The antibacterial activity in the serum at one hour ranged from 15.2 to 18.4 mcg. per ml. with an average of 16.3 mcg per ml. Activity of serum declined rapidly thereafter and that serum levels fell to 1.7 mcg. per ml. after six hours. The blood level of LCM in healthy adults who were given 600 mg of LCM intramuscularly reached maximum of 6.4 mcg per ml. one hour after administration. Even at six hours after intramuscular injection, clinically effective serum LCM concentration 1.9 mcg per ml. was still demonstrable.
