Abstract
Aldosterone is a hormone of adrenal gland which promotes Na-K-exchange in the distal kidney tubules.
It was found that aldosterone causes a depression of cochlear microphonics in guinea pigs. In this paper, effect of aldosterone on endocochlear DC potential was studied. With the injection 0.5mg/kg of aldosterone, endocochlear DC potential caused a de- pression. Therefore it seems that aldosterone acts to the stria vascularis and promotes the absorption of sodium ion the endolymph. The depression of cochlear microphonics caused by aldosterone depends on the changes of ion concentrations in the endolymph and a depression of endocochlear DC potential.
