Successful Immunotherapy of Candida Esophagitis with Transfer Factor

Abstract

A case of Candida esophagitis which was reconstituted the cellular immune deficiency with the transfer factor is reported. This case was diagnosed as chronic mucocutaneous candidiasis with esophageal involvement by various clinical and laboratory examinations. The lesion was circumuscribed mainly in esophageal mucosa, and no definite cause such as improper use of steroids or antibiotics was suggested. Agglutinating antibody titer against C. albicans was extremely higher than those of normal controls and localized superficial candidiasis patients. On the other hand, delayed hypersensitivity reactions to the Candida antigen and also to PPD were im- paired. Neither endocrine abnomalities, hypovitaminosis A nor abnormal iron metabolism have been recognized.
Satisfactory result was obtained by the treatment with clotrimazole and transfer factor. Cellular immune state was successfully reconstituted. Clinical and immunological observations and sustaining administration of transfer factor have been continued.