Abstract
Suspension-type cultured cells (MC cells) derived in our laboratory in 1976 from human carcinoma of the maxillary sinus (squamous cell carcinoma) were transfered to five congenitally athymic mouse mutants,“nude”, at doses of 107 cells. Tumor formation was found locally at the site of inoculation within 10 days in every case with no distant metastases. The tumors grew rapidly and constantly and continued to grow until death (within 39 days) of the hosts. Histopathological examination of the transplanted tumors revealed the proliferation of malignant cells and shows similarity to that of the human donor material. It could be concluded, therefore, that the cultured cell, used in our study, is a established cell line of human carcinoma of the maxillary sinus.
