Abstract
Seventeen cases of malignant tumor of the paranasal sinuses were treated with the intra-arterial infusion of 0.12 95 hydrogen peroxide as a supplementary means of radical operation or radiation therapy during the last two years and four months.
The hydrogen peroxide solution was infused with an infusion pump in about an hour period. This infusion was performed everyday for about 10 days. Changes in the oxygen tension (Po2) of normal tissues and tumor tissues by hydrogen peroxide infusion in these cases were measured with a mass spectrometer (MEDSPECT, MS 8).
The results were summarized as follows:
1. Mean tissue Po2 were not different between normal tissues and tumor tissues
2. On the first hydrogen peroxide infusion, Po2 in the normal and tumor tissues builds up slowly during the arterial infusion and tends to drop off rather sharply when the infusion is stopped. On the 5-8 th hydrogen peroxide infusion, Po2 in theses tissues builds up slowly during the arterial infusion. But, when the infusion is stopped, Po2 tends either to decrease gradually or to increase gradually.
3. Both in the normal tissues and tumor tissues, the tissue Po2 and the increment of the tissue Po2 on the 5-8th hydrogen peroxide infusion tend to fall.
