Double-Blind Trial of Bacampicillin in the Treatment of Acute Suppurative Otitis media and Acute Tonsillitis

Abstract

In acute suppurative otitis media and acute tonsillitis (including peritonsillitis and peritonsillar abscess), efficacy, safety and usefulness of bacampicillin (BAPC) were compared with those of amoxycillin (AMPC), as a standard drug, by a double blind controlled study. The following results were obtained;
1) The global improvement rating (GIR) judged by doctors in acute suppurative otitis media showed no significant difference between both groups, but BAPC was superior to AMPC in acute tonsillitis (P<0.05).
2) No significant difference was observed in the incidence of side effects between both groups.
3) BAPC was superior to AMPC in regard to the global utility rating judged by doctors and evaluation committee in acute tonsillitis (P<0.05), although there was no significant difference between both groups in acute suppurative otitis media.
As mentioned above, BAPC was superior to AMPC in regard to GIR in acute tonsillitis and GIR in single infections of β-strept. in the disease However, there was no significant difference between both groups in not only GIR in acute suppurative otitis media but also sensitivity of β-strept. to ABPC (active compound of BAPC) and AMPC.