Abstract
One case of localized, tumor-formed laryngeal amyloidosis has been reported. The adequate use of special staining techniques was emphasized in the histological diagnosis of localized amyloidosis in the larynx.
A 36 years old man had complained of persistent hoarseness of about 17 months duration. Examination under direct laryngoscopy revealed a marked, tumorous thickening of the left false cord without any ulceration of the overlying mucous membrane. The tissue removed by the incisional biopsy lunder general anesthesia showed massive submucosal amyloid deposition. After preliminary tracheotomy, amyloid mass was removed through the laryngofissure approach. The denuded area was covered by the free mucous membrane graft from the nasal septum.
Histological examination showed extensive deposits of homogenous eosinophilic substances in fibrous, musclar and glandular tissues. These substances were stained with Congo red and showed metachromasia, then the diagnosis of amyloidosis was confirmed.
Although the patient's hoarseness did not fully improve, he has remained free from the disease for 17 months after the operation.
