Abstract
This study was performed to clarify the cochlear microcirculation after the administration of Kallikrein in guinea pigs, by the methods of intravital vascular perfusion of the pigment and of the physical measurement of auditory brain response (ABR).
In the animals which received Kallikrein of the dosis of 2 biological units per kg body weight, the fine and clear dilatation of the radiating arterioles, spiral prominence vessel, arterio-venous anastomoses, venules at the basilar membrane and collecting venules were observed, in comparison with the control animals.
The threshold of measurement of ABR to 15000Hz pure tone showed the decreasing of 10dB after the administration of Kallikrein.
These results suggested the activation of the cochlear circulation due to the effects of Kallikrein.
