Abstract
Clinical effecacy of Combipenix®(ampicillin-dicloxacillin combination product) on acute excavation of chronic otitis media was studied in 47 patients, especially in the cases caused by mixed infection.
The age range was 20 to 75 years, and 28 were male.
Middle ear discharge was also examined bacteriologically and there were 18 cases in which more than two kinds of pathogen had been proved.
Mixed infections with gram-positive bacteria were 7 cases, with gram-positive and gram-negative bacteria were 7 cases and with gram-negative bacteria were 4 cases.
Clinical effects of these 18 cases treated with Combipenix® were as follows; excellent effect was 27.8%, good was27.8% and total was 55.6%.
Synergistic effects ofCombipenix® were shown in some organisms lisolated from these patients.
No adverse side effect was observed except one case with eruption, however, this case could not bedefined clearly whether symptom attributed to the drug.
It is considered that Combipenix® is effective in therapy for chronic suppurative otitis media caused by mixed infections other than pseudomonad.
