Abstract
This study has been carried out in order to clarify the mechanism of wound healing of the vocal folds which vibrates very frequently during phonation. The wound was artificially made in the superficial layer of lamina propria of the canine vocal fold. The wound was uniformly obtained by use of a specially designed device. The vocal fold injured was studied biochemically, phonodynamically and histologically.
The first, the author has succeeded in improvement of the method for estimation of hydroxyproline which is said to be one of healing indexes.
The second, by use of the method mentioned above, the author performed experimental studies and obtained the results as follows.
1) The value of hydroxyproline increased and was saturated in 2 weeks after the wound injury.
2) The epithelium was almost regenerated in two weeks and fibrosis in the submucous layer was found in 3 weeks.
3) The excellent vibratory pattern was obtained after two weeks. From the results obtained, the author concludes that for the wound mentioned above, the whole course of the wound healing in the vocal fold is established between two and three weeks.
