Abstract
It is important to evaluate the effect of antibiotic drugs that measure the serum tissue concentration of the drugs. We measured the serum and tissue of the maxillary sinus concentration of Cefotiam by the Agar Well Assey. One gram of Cefotiam was administered intravenously over fifteen minutes period to the patients who were diagnosed as chronic sinusitis. The patients included fourteen males and eight females. We extricated the mucosa of the maxillary sinus by the CALDWELL-LUC operation. The serum and tissue concentrations were analyzed by the Clinical Pharmakokinetics, and it was found that the serum reached a peak concentration of 84.9μg/ml within fifteen minutes after injection, and the tissue reached a peak concentration of 29.5μg/ml within twenty one minutes after injection. Serum and tissue concentration declined together. The Cefotiam was detected at a higher tissue concentration one hour after injection than was the MIC of bacilli in chronic sinusitis.
