Abstract
Effects of peroral administration of glycerol (50 % glycerol, 12 ml/kg) on intra-facial nerve pressure was studied in five guinea pigs. A servo-nulling system (WPI Micro-Pressure System Model 900) was used to measure the interstitial fluid pressure of the facial nerve. At the same time, cerebrospinal fluid pressure was recorded. Glycerol lowered the facial nerve pressure as well as the cerebrospinal fluid pressure. We conclude that the decrease in the cerebrospinal fluid pressure was transmitted to the facial nerve via a fluid system in the facial nerve which connects with the cerebrospinal fluid. The present paper is the first to report the direct effect of glycerol on the interstitial fluid pressure in the facial nerve.
